💉 Unfractionated Heparin (UFH) Weight-Based Dosing
UseChoose an initial weight-based UFH regimen; subsequent rates are titrated by aPTT or anti-Xa and your institu…
Loading calculator…
SourceRaschke RA, et al. Ann Intern Med 1993 (VTE); 2025 ACC/AHA ACS guideline (update pending) (ACS); AC…
Runs locally in your browser (no PHI uploaded). For licensed clinicians — not a substitute for clinical judgement.
Stored on this device for revisit reminders
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
- Who it is for
- Adults in whom IV unfractionated heparin has already been chosen, e.g. high-risk PE, possible reperfusion, severe renal impairment, or severe obesity.
- Who it is not for
- Most patients without high-risk PE: LMWH, fondaparinux, or a DOAC is preferred for initial anticoagulation. Known or suspected HIT: no heparin. Children: do not apply this adult regimen.
- Formula and variables
- Weight (kg) and indication. Bolus and starting infusion follow this page's formula and are not repeated here. The VTE row follows the Raschke 1993 weight-based nomogram; the ACS row follows the 2014 AHA/ACC NSTE-ACS guideline.
- Result → next step
- This page gives the starting regimen only. Then titrate by aPTT or anti-Xa with your institution's nomogram. Monitor platelets (HIT), bleeding, and renal function. Duration opens the anticoagulation-duration page.Duration after confirmation →
- Guideline and review date
- 2019 ESC/ERS PE; China PTE guideline 2025; Raschke 1993; 2014 AHA/ACC NSTE-ACS; ACCP 2012 · reviewed 2026-10-06
Scene next step
📋anticoagOpen scene pack →Related scores
Score + version; reference only — not a substitute for care · no HIS write
Paste the link in Slack, Teams, X, or LinkedIn — the preview image comes from this page’s Open Graph card.
Methodology · worked example, guidelines & full notes
Clinical takeaway
Recheck aPTT 6 h after starting and after each rate change.
When to use
Choose an initial weight-based UFH regimen; subsequent rates are titrated by aPTT or anti-Xa and your institutional nomogram.
How it works
VTE: 80 U/kg bolus + 18 U/kg/h. ACS anticoagulation depends on the reperfusion strategy; see the cited guideline (2025 ACC/AHA ACS guideline, PMID 40014670). Target aPTT control or anti-Xa.
Key points
- Recheck aPTT 6 h after starting and after each rate change.
- Monitor platelets for heparin-induced thrombocytopenia (HIT).
- Watch for bleeding and impaired renal function.
- Always titrate by your institution's nomogram.
References
- [Original paper / primary source]Raschke RA, et al. Ann Intern Med 1993 (VTE); 2025 ACC/AHA ACS guideline (update pending) (ACS); ACCP 2012 (anti-Xa)
- [Guideline basis]2025 ACC/AHA guideline for acute coronary syndromes (PMID 40014670)
- [Guideline basis]Guideline source: 2019 ESC/ERS Guidelines for the diagnosis and management of acute pulmonary embolism (Konstantinides SV, et al. Eur Heart J 2020;41(4):543–603. doi:10.1093/eurheartj/ehz405); Chinese guidelines for the diagnosis, treatment, prophylaxis and management of pulmonary thromboembolism, 2025 edition (Natl Med J China 2025;105(26):2162–2194. doi:10.3760/cma.j.cn112137-20250509-01141) (Table 8: aPTT monitoring and adjustment for IV UFH). VTE row: Raschke RA, et al. Ann Intern Med 1993;119(9):874–881. doi:10.7326/0003-4819-119-9-199311010-00002 (weight-based nomogram). ACS row: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes (Amsterdam EA, et al. Circulation 2014;130(25):e344–e426. doi:10.1161/CIR.0000000000000134; Class I, Level of Evidence B).
- Raschke RA, et al. Ann Intern Med 1993;119:874–881 (PMID 8214998)
Verification & sources · governance
FAQ
Frequently asked questions
- What are the limits and cautions when using Unfractionated Heparin (UFH) Weight-Based Dosing?
- For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
- Does Unfractionated Heparin (UFH) Weight-Based Dosing upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.