🩸 GELF Criteria (Follicular Lymphoma High Tumor Burden)
UseWhen to use: FL treatment-vs-observe decisions.
StrataGELF-positive usually favors initiating therapy; GELF-negative may allow watchful waiting.
LimitsWhen not to use: transformed / aggressive histology pathways alone. · Pitfall: ignoring patient symptoms outside list. · Not a sole regimen choice.
SourceGELF (Groupe d'Etude des Lymphomes Folliculaires) high-tumor-burden criteria
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
Any-one positive.
When to use
When to use: FL treatment-vs-observe decisions.
How it works
Any one classic GELF criterion → high burden.
Key points
- Any-one positive.
- Pairs with FLIPI.
- Next: stage / grade / PET.
References
- GELF (Groupe d'Etude des Lymphomes Folliculaires) high-tumor-burden criteria
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Any nodal/extranodal mass >7 cm | No |
|---|---|
| ≥3 nodal sites each >3 cm | No |
| B symptoms | No |
| Symptomatic splenomegaly | No |
| Organ compression / risk (ureter, etc.) | No |
| Pleural effusion or ascites | No |
| Leukemic phase (>5×10⁹/L circulating lymphoma cells) | No |
| Cytopenias (ANC <1.0×10⁹/L and/or Plt <100×10⁹/L) | No |
→GELFNegative
- Positive criteria：0
- Cue：GELF negative — may support watch-and-wait if otherwise appropriate
| Any nodal/extranodal mass >7 cm | Yes |
|---|---|
| ≥3 nodal sites each >3 cm | Yes |
| B symptoms | Yes |
| Symptomatic splenomegaly | Yes |
| Organ compression / risk (ureter, etc.) | Yes |
| Pleural effusion or ascites | Yes |
| Leukemic phase (>5×10⁹/L circulating lymphoma cells) | Yes |
| Cytopenias (ANC <1.0×10⁹/L and/or Plt <100×10⁹/L) | Yes |
→GELFPositive(8 criteria)
- Positive criteria：8
- Cue：GELF positive — high tumor burden; discuss treatment
Verification & sources · governance
FAQ
Frequently asked questions
- Does GELF Criteria (Follicular Lymphoma High Tumor Burden) upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is GELF Criteria (Follicular Lymphoma High Tumor Burden) calculated in practice? Can you show a worked example?
- Inputs: Any nodal/extranodal mass >7 cm No, ≥3 nodal sites each >3 cm No, B symptoms No, Symptomatic splenomegaly No, Organ compression / risk (ureter, etc.) No, Pleural effusion or ascites No, Leukemic phase (>5×10⁹/L circulating lymphoma cells) No, Cytopenias (ANC <1.0×10⁹/L and/or Plt <100×10⁹/L) No → Result: GELF Negative（Positive criteria: 0, Cue: GELF negative — may support watch-and-wait if otherwise appropriate） Inputs: Any nodal/extranodal mass >7 cm Yes, ≥3 nodal sites each >3 cm Yes, B symptoms Yes, Symptomatic splenomegaly Yes, Organ compression / risk (ureter, etc.) Yes, Pleural effusion or ascites Yes, Leukemic phase (>5×10⁹/L circulating lymphoma cells) Yes, Cytopenias (ANC <1.0×10⁹/L and/or Plt <100×10⁹/L) Yes → Result: GELF Positive (8 criteria)（Positive criteria: 8, Cue: GELF positive — high tumor burden; discuss treatment）