🩸 Dutch Lipid Clinic Network FH Criteria
UseWhen to use: suspected familial hypercholesterolemia before/alongside genetic testing.
StrataDefinite / probable / possible / unlikely FH; plan cascade screening if elevated.
LimitsWhen not to use: untreated secondary hyperlipidemia unaddressed. · Pitfall: treated LDL underestimates points. · Not a sole PCSK9 auth.
SourceDutch Lipid Clinic Network FH criteria
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
DLCN points.
When to use
When to use: suspected familial hypercholesterolemia before/alongside genetic testing.
How it works
Sum family + clinical + exam + LDL-C + DNA points; >8 / 6–8 / 3–5 / <3.
Key points
- DLCN points.
- Four classes.
- Next: genetics / family cascade.
References
- Dutch Lipid Clinic Network FH criteria
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Family history (highest applicable) | 1° relative premature CAD or LDL >95th (+1) |
|---|---|
| Clinical history (highest applicable) | Patient premature cerebral/peripheral VD (+1) |
| Physical exam (highest applicable) | Arcus cornealis <45 y (+4) |
| LDL-C category | 5.0–6.4 mmol/L (190–249) (+3) |
| Pathogenic LDLR / APOB / PCSK9 variant | No / not tested (0) |
→DLCN9pts
- Classification：Definite FH (>8)
| Family history (highest applicable) | None (0) |
|---|---|
| Clinical history (highest applicable) | None (0) |
| Physical exam (highest applicable) | None (0) |
| LDL-C category | <4.0 mmol/L (<155 mg/dL) (0) |
| Pathogenic LDLR / APOB / PCSK9 variant | No / not tested (0) |
→DLCN0pts
- Classification：Unlikely FH (<3)
Verification & sources · governance
FAQ
Frequently asked questions
- Does Dutch Lipid Clinic Network FH Criteria upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is Dutch Lipid Clinic Network FH Criteria calculated in practice? Can you show a worked example?
- Inputs: Family history (highest applicable) 1° relative premature CAD or LDL >95th (+1), Clinical history (highest applicable) Patient premature cerebral/peripheral VD (+1), Physical exam (highest applicable) Arcus cornealis <45 y (+4), LDL-C category 5.0–6.4 mmol/L (190–249) (+3), Pathogenic LDLR / APOB / PCSK9 variant No / not tested (0) → Result: DLCN 9 pts（Classification: Definite FH (>8)） Inputs: Family history (highest applicable) None (0), Clinical history (highest applicable) None (0), Physical exam (highest applicable) None (0), LDL-C category <4.0 mmol/L (<155 mg/dL) (0), Pathogenic LDLR / APOB / PCSK9 variant No / not tested (0) → Result: DLCN 0 pts（Classification: Unlikely FH (<3)）