🧠 CNS-IPI (CNS Relapse Risk in DLBCL)
UseWhen to use: newly diagnosed DLBCL before deciding CNS prophylaxis.
Strata0–1 low (~0.6%), 2–3 intermediate (~3.4%), 4–6 high (~10.2%) CNS relapse.
LimitsWhen not to use: non-DLBCL histologies without adaptation. · Pitfall: missing testicular/breast special sites. · Not a sole IT/HD-MTX mandate.
SourceCNS-IPI (Schmitz et al., JCO) DLBCL CNS relapse
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
Six factors.
When to use
When to use: newly diagnosed DLBCL before deciding CNS prophylaxis.
How it works
+1 each: age >60, LDH >ULN, ECOG >1, stage III/IV, extranodal >1, kidney/adrenal.
Key points
- Six factors.
- Three risk groups.
- Next: prophylaxis board discussion.
References
- [Guideline / primary source]CNS-IPI (Schmitz et al., JCO) DLBCL CNS relapse
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Age >60 years | No (0) |
|---|---|
| LDH > upper limit of normal | No (0) |
| ECOG performance status >1 | No (0) |
| Ann Arbor stage III/IV | No (0) |
| Extranodal involvement >1 site | No (0) |
| Kidney and/or adrenal involvement | No (0) |
→CNS-IPI0/6
- Risk group：Low (0–1) — derivation CNS relapse ~0.6%
| Age >60 years | Yes (+1) |
|---|---|
| LDH > upper limit of normal | Yes (+1) |
| ECOG performance status >1 | Yes (+1) |
| Ann Arbor stage III/IV | Yes (+1) |
| Extranodal involvement >1 site | Yes (+1) |
| Kidney and/or adrenal involvement | Yes (+1) |
→CNS-IPI6/6
- Risk group：High (4–6) — ~10.2%; discuss CNS prophylaxis strategy
Verification & sources · governance
FAQ
Frequently asked questions
- Does CNS-IPI (CNS Relapse Risk in DLBCL) upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is CNS-IPI (CNS Relapse Risk in DLBCL) calculated in practice? Can you show a worked example?
- Inputs: Age >60 years No (0), LDH > upper limit of normal No (0), ECOG performance status >1 No (0), Ann Arbor stage III/IV No (0), Extranodal involvement >1 site No (0), Kidney and/or adrenal involvement No (0) → Result: CNS-IPI 0 /6（Risk group: Low (0–1) — derivation CNS relapse ~0.6%） Inputs: Age >60 years Yes (+1), LDH > upper limit of normal Yes (+1), ECOG performance status >1 Yes (+1), Ann Arbor stage III/IV Yes (+1), Extranodal involvement >1 site Yes (+1), Kidney and/or adrenal involvement Yes (+1) → Result: CNS-IPI 6 /6（Risk group: High (4–6) — ~10.2%; discuss CNS prophylaxis strategy）