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🩸 Thrombocytopenia Differential

UseTriage thrombocytopenia after excluding a spurious result, localising the mechanism and flagging emergencies.

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SourceStandard approach to thrombocytopenia; ASH guidance on ITP/TTP/HIT

Runs locally in your browser (no PHI uploaded). For licensed clinicians — not a substitute for clinical judgement.
Stored on this device for revisit reminders

This-shift next steps

After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.

Scene next step
📋hematologyOpen scene pack →
Related scores
Matching pathway
🧭febrile_neutropeniaOpen pathway →
Score + version; reference only — not a substitute for care · no HIS write

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Methodology · worked example, guidelines & full notes
Clinical takeaway

Exclude spurious (EDTA) thrombocytopenia with a citrate recheck and smear.

When to use

Triage thrombocytopenia after excluding a spurious result, localising the mechanism and flagging emergencies.

How it works

Severity (×10⁹/L): mild 100–150, moderate 50–100, severe 20–50, very severe < 10–20.

Key points

  • Exclude spurious (EDTA) thrombocytopenia with a citrate recheck and smear.
  • Schistocytes + haemolysis suggest a thrombotic microangiopathy.
  • HIT: calculate the 4Ts; stop heparin and switch anticoagulant.
  • Platelet transfusion may be harmful in TTP/HIT unless life-threatening bleeding.

References

Worked calculation

The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.

ViewMechanism

→Key pointMechanistic classification

  • Reduced production：Marrow: aplasia, infiltration (leukaemia/metastasis), chemo/drugs, B12/folate deficiency, alcohol, infection
  • Destruction · immune：ITP, drug-induced, HIT, post-transfusion purpura, autoimmune disease
  • Destruction · non-immune：TTP/HUS, DIC, mechanical (valve), pre-eclampsia/HELLP
ViewSeverity & risk

→Key pointSeverity & bleeding risk (×10⁹/L)

  • Mild 100–150：Usually asymptomatic, recheck on follow-up
  • Moderate 50–100：Most procedures/surgery need assessment
  • Severe 20–50：Increased surgical/trauma bleeding risk
Verification & sources · governance
FAQ

Frequently asked questions

What are the limits and cautions when using Thrombocytopenia Differential?
For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
Does Thrombocytopenia Differential upload patient data? Where is it calculated?
Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
How is Thrombocytopenia Differential calculated in practice? Can you show a worked example?
Inputs: View Mechanism → Result: Key point Mechanistic classification（Reduced production: Marrow: aplasia, infiltration (leukaemia/metastasis), chemo/drugs, B12/folate deficiency, alcohol, infection, Destruction · immune: ITP, drug-induced, HIT, post-transfusion purpura, autoimmune disease, Destruction · non-immune: TTP/HUS, DIC, mechanical (valve), pre-eclampsia/HELLP） Inputs: View Severity & risk → Result: Key point Severity & bleeding risk (×10⁹/L)（Mild 100–150: Usually asymptomatic, recheck on follow-up, Moderate 50–100: Most procedures/surgery need assessment, Severe 20–50: Increased surgical/trauma bleeding risk）
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