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🦠 Systemic Immune-Inflammation Index (SII)

UseResearch-oriented prognostic inflammatory marker, mainly in oncology.

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SourceHu B, et al. Clin Cancer Res 2014

Runs locally in your browser (no PHI uploaded). For licensed clinicians — not a substitute for clinical judgement.
Stored on this device for revisit reminders

This-shift next steps

After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.

Scene next step
📋hematologyOpen scene pack →
Related scores
Matching pathway
🧭febrile_neutropeniaOpen pathway →
Score + version; reference only — not a substitute for care · no HIS write

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Methodology · worked example, guidelines & full notes
Clinical takeaway

Higher SII linked to worse prognosis in several cancers.

When to use

Research-oriented prognostic inflammatory marker, mainly in oncology.

How it works

SII = platelets × neutrophils ÷ lymphocytes (absolute counts).

Key points

  • Higher SII linked to worse prognosis in several cancers.
  • Hu 2014 used 330 in hepatocellular carcinoma; no universal cut-off.
  • Not a standalone clinical decision tool.

References

Worked calculation

The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.

Platelets250 ×10⁹/L
Absolute neutrophils6.0 ×10⁹/L
Absolute lymphocytes2.0 ×10⁹/L

→SII750×10⁹/L

  • Formula：platelets × neutrophils / lymphocytes
  • Note：Higher SII has been associated with worse prognosis in several cancers; Hu 2014 used 330 as the optimal cut-off after curative resection of hepatocellular carcinoma; there is no universal cut-off.
Verification & sources · governance
FAQ

Frequently asked questions

What are the limits and cautions when using Systemic Immune-Inflammation Index (SII)?
For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
Does Systemic Immune-Inflammation Index (SII) upload patient data? Where is it calculated?
Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
How is Systemic Immune-Inflammation Index (SII) calculated in practice? Can you show a worked example?
Inputs: Platelets 250 ×10⁹/L, Absolute neutrophils 6.0 ×10⁹/L, Absolute lymphocytes 2.0 ×10⁹/L → Result: SII 750 ×10⁹/L（Formula: platelets × neutrophils / lymphocytes, Note: Higher SII has been associated with worse prognosis in several cancers; Hu 2014 used 330 as the optimal cut-off after curative resection of hepatocellular carcinoma; there is no universal cut-off.）
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