🩸 Sepsis-Induced Coagulopathy (ISTH SIC)
UseWhen to use: infected/septic patients when screening early coagulopathy before overt DIC.
StrataSIC ≥4 supports early sepsis coagulopathy — compare with ISTH overt DIC if needed.
LimitsWhen not to use: without suspected infection/sepsis. · Pitfall: equating SIC with full DIC. · Not a sole transfusion protocol.
SourceISTH SIC (Iba) sepsis-induced coagulopathy score
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
Threshold ≥4.
When to use
When to use: infected/septic patients when screening early coagulopathy before overt DIC.
How it works
Platelets 0–2 + PT-INR 0–2 + total SOFA 0–2; ≥4 = SIC.
Key points
- Threshold ≥4.
- Earlier than overt DIC.
- Next: cause / ISTH DIC.
References
- [Guideline / primary source]ISTH SIC (Iba) sepsis-induced coagulopathy score
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Platelet count (×10⁹/L) | 1 — 100–149 |
|---|---|
| PT-INR | 1 — >1.2 to ≤1.4 |
| Total SOFA score | 1 — SOFA = 1 |
→SIC3/6
- Threshold：≥4
- Cue：<4 — does not meet SIC threshold (does not exclude DIC)
| Platelet count (×10⁹/L) | 0 — ≥150 |
|---|---|
| PT-INR | 0 — ≤1.2 |
| Total SOFA score | 0 — SOFA = 0 |
→SIC0/6
- Threshold：≥4
- Cue：<4 — does not meet SIC threshold (does not exclude DIC)
Verification & sources · governance
FAQ
Frequently asked questions
- Does Sepsis-Induced Coagulopathy (ISTH SIC) upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is Sepsis-Induced Coagulopathy (ISTH SIC) calculated in practice? Can you show a worked example?
- Inputs: Platelet count (×10⁹/L) 1 — 100–149, PT-INR 1 — >1.2 to ≤1.4, Total SOFA score 1 — SOFA = 1 → Result: SIC 3 /6（Threshold: ≥4, Cue: <4 — does not meet SIC threshold (does not exclude DIC)） Inputs: Platelet count (×10⁹/L) 0 — ≥150, PT-INR 0 — ≤1.2, Total SOFA score 0 — SOFA = 0 → Result: SIC 0 /6（Threshold: ≥4, Cue: <4 — does not meet SIC threshold (does not exclude DIC)）