🧴 RegiSCAR DRESS Validation Score
UseWhen to use: severe drug rash with systemic features when DRESS is on the differential.
Strata<2 no; 2–3 possible; 4–5 probable; >5 definite.
LimitsWhen not to use: replacing immediate culprit-drug cessation. · Pitfall: missing visceral involvement. · Not a sole steroid protocol.
SourceKardaun SH, et al. RegiSCAR DRESS. Br J Dermatol 2013. doi:10.1111/bjd.12501
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
Validation score.
When to use
When to use: severe drug rash with systemic features when DRESS is on the differential.
How it works
Fever, nodes, atypical lymphs, eosinophilia, rash, biopsy, organs, ≥15-day course, alternatives excluded.
Key points
- Validation score.
- Four classes.
- Next: stop culprit + supportive care.
References
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Fever ≥38.5 °C | No/Unknown (−1) |
|---|---|
| Enlarged lymph nodes ≥2 sites >1 cm | No (0) |
| Atypical lymphocytes | No (0) |
| Eosinophilia | 700–1499 or 10–19.9% (+1) |
| Skin rash extent >50% BSA | No (0) |
| ≥2 of edema/infiltration/purpura/scaling | Unknown (0) |
| Biopsy suggesting DRESS | No (−1) |
| Internal organ involvement | 1 organ (+1) |
| Resolution ≥15 days | No/Unknown (−1) |
| ≥3 biologic tests exclude alternatives | No (0) |
→RegiSCAR-1pts
- Class：<2 — no DRESS
| Fever ≥38.5 °C | No/Unknown (−1) |
|---|---|
| Enlarged lymph nodes ≥2 sites >1 cm | No (0) |
| Atypical lymphocytes | No (0) |
| Eosinophilia | None / <700 or <10% (0) |
| Skin rash extent >50% BSA | No (0) |
| ≥2 of edema/infiltration/purpura/scaling | No (−1) |
| Biopsy suggesting DRESS | No (−1) |
| Internal organ involvement | 0 (0) |
| Resolution ≥15 days | No/Unknown (−1) |
| ≥3 biologic tests exclude alternatives | No (0) |
→RegiSCAR-4pts
- Class：<2 — no DRESS
Verification & sources · governance
FAQ
Frequently asked questions
- Does RegiSCAR DRESS Validation Score upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is RegiSCAR DRESS Validation Score calculated in practice? Can you show a worked example?
- Inputs: Fever ≥38.5 °C No/Unknown (−1), Enlarged lymph nodes ≥2 sites >1 cm No (0), Atypical lymphocytes No (0), Eosinophilia 700–1499 or 10–19.9% (+1), Skin rash extent >50% BSA No (0), ≥2 of edema/infiltration/purpura/scaling Unknown (0), Biopsy suggesting DRESS No (−1), Internal organ involvement 1 organ (+1)… → Result: RegiSCAR -1 pts（Class: <2 — no DRESS） Inputs: Fever ≥38.5 °C No/Unknown (−1), Enlarged lymph nodes ≥2 sites >1 cm No (0), Atypical lymphocytes No (0), Eosinophilia None / <700 or <10% (0), Skin rash extent >50% BSA No (0), ≥2 of edema/infiltration/purpura/scaling No (−1), Biopsy suggesting DRESS No (−1), Internal organ involvement 0 (0)… → Result: RegiSCAR -4 pts（Class: <2 — no DRESS）