🧬 ICANS Grade (ASTCT Neurotoxicity)
UseWhen to use: ICE-monitored patients after cellular therapy.
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StrataGrade ≥2 usually triggers protocolized neurology/ICU escalation.
LimitsWhen not to use: without product-specific toxicity SOP. · Pitfall: missing non-convulsive status. · Grade CRS in parallel.
SourceLee DW et al. ASTCT ICANS consensus grading
Runs locally in your browser (no PHI uploaded). For licensed clinicians — not a substitute for clinical judgement.
Stored on this device for revisit reminders
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
Clinical takeaway
Max of domains.
When to use
When to use: ICE-monitored patients after cellular therapy.
How it works
ICANS grade = max(ICE-derived grade, consciousness, seizures, motor, ICP/edema grades).
Key points
- Max of domains.
- ICE drives much of grade.
- Next: CRS grade / tocilizumab pathways as indicated.
References
- Lee DW et al. ASTCT ICANS consensus grading
Verification & sources · governance
FAQ
Frequently asked questions
- Does ICANS Grade (ASTCT Neurotoxicity) upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.