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🩸 Hemolysis Marker Interpretation

UseConfirm haemolysis, then classify by DAT (immune vs non-immune) and the intravascular/extravascular pattern t…

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SourceStandard interpretation of haemolysis markers and the direct antiglobulin test

Runs locally in your browser (no PHI uploaded). For licensed clinicians — not a substitute for clinical judgement.
Stored on this device for revisit reminders

This-shift next steps

After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.

Scene next step
📋hematologyOpen scene pack →
Related scores
Matching pathway
🧭febrile_neutropeniaOpen pathway →
Score + version; reference only — not a substitute for care · no HIS write

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Methodology · worked example, guidelines & full notes
Clinical takeaway

LDH ↑ with haptoglobin ↓ is sensitive and specific for haemolysis.

When to use

Confirm haemolysis, then classify by DAT (immune vs non-immune) and the intravascular/extravascular pattern to find the cause.

How it works

Haemolysis: LDH ↑ + haptoglobin ↓ + indirect bilirubin ↑ + reticulocytes ↑.

Key points

  • LDH ↑ with haptoglobin ↓ is sensitive and specific for haemolysis.
  • DAT separates immune (AIHA) from non-immune haemolysis.
  • Schistocytes flag microangiopathic haemolysis (MAHA).
  • MAHA needs urgent workup for TTP/HUS/DIC.

References

Worked calculation

The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.

ViewIntra- vs extravascular

→Key pointIntravascular vs extravascular

  • Intravascular：Haptoglobin markedly ↓/undetectable, haemoglobinuria, haemosiderinuria, free Hb ↑ (mechanical valve, PNH, severe immune, transfusion reaction)
  • Extravascular：Splenic/hepatic clearance, spherocytes, marked indirect bilirubin ↑ (warm-antibody AIHA, hereditary spherocytosis)
ViewLab markers

→Key pointLab markers of haemolysis

  • Increased：LDH ↑, indirect (unconjugated) bilirubin ↑, reticulocytes ↑
  • Decreased：Haptoglobin ↓
  • Smear：Schistocytes (MAHA), spherocytes (immune/hereditary), bite cells (G6PD)
Verification & sources · governance
FAQ

Frequently asked questions

What are the limits and cautions when using Hemolysis Marker Interpretation?
For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
Does Hemolysis Marker Interpretation upload patient data? Where is it calculated?
Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
How is Hemolysis Marker Interpretation calculated in practice? Can you show a worked example?
Inputs: View Intra- vs extravascular → Result: Key point Intravascular vs extravascular（Intravascular: Haptoglobin markedly ↓/undetectable, haemoglobinuria, haemosiderinuria, free Hb ↑ (mechanical valve, PNH, severe immune, transfusion reaction), Extravascular: Splenic/hepatic clearance, spherocytes, marked indirect bilirubin ↑ (warm-antibody AIHA, hereditary spherocytosis)） Inputs: View Lab markers → Result: Key point Lab markers of haemolysis（Increased: LDH ↑, indirect (unconjugated) bilirubin ↑, reticulocytes ↑, Decreased: Haptoglobin ↓, Smear: Schistocytes (MAHA), spherocytes (immune/hereditary), bite cells (G6PD)）
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