🦠 Duke-ISCVID 2023 IE Criteria
UseWhen to use: suspected IE when integrating microbiologic, imaging, and clinical minors.
StrataDefinite / possible / rejected guides workup intensity and therapy planning.
LimitsWhen not to use: ignoring culture-negative special pathogens. · Pitfall: under-counting imaging majors. · Not a sole antibiotic-duration order.
SourceUS layer: Infective Endocarditis: Diagnosis, Antibiotic Therapy, and Management: A Scientific State…
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
Paste the link in Slack, Teams, X, or LinkedIn — the preview image comes from this page’s Open Graph card.
Methodology · worked example, guidelines & full notes
2023 update.
When to use
When to use: suspected IE when integrating microbiologic, imaging, and clinical minors.
How it works
Definite: pathology OR 2 major OR 1 major+3 minor OR 5 minor; possible: 1 major+1 minor OR 3 minor.
Key points
- 2023 update.
- Major/minor logic.
- Next: ID/cardiology board.
References
- [Guideline / primary source]US layer: Infective Endocarditis: Diagnosis, Antibiotic Therapy, and Management: A Scientific Statement From the American Heart Association (DeSimone DC, et al. Circulation. Published online September 8, 2026. doi:10.1161/CIR.0000000000001466; endorsed by ISCVID). This AHA Scientific Statement uses the 2023 Duke-ISCVID criteria for the contemporary diagnosis of IE. This page applies the classification rules of Fowler 2023; criteria unchanged.
- Fowler VG Jr, et al. The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria. Clin Infect Dis 2023;77(4):518-526. doi:10.1093/cid/ciad271
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Pathologic proof (microorganism in vegetation/abscess OR pathologic lesions) | No (0) |
|---|---|
| Major: typical IE blood-culture / molecular criterion met | No (0) |
| Major: imaging (echo/CT/PET) OR surgical major criterion met | No (0) |
| Minor: predisposition (prior IE, prosthetic valve, CHD, IDU, etc.) | No (0) |
| Minor: fever ≥38.0 °C | No (0) |
| Minor: vascular phenomena | No (0) |
| Minor: immunologic phenomena | No (0) |
| Minor: microbiologic evidence not meeting major | No (0) |
| Clear alternative diagnosis OR resolution ≤4 d antibiotics OR no IE at surgery/autopsy | No (0) |
→Duke-ISCVIDRejected
- Major / minor：0 / 0
| Pathologic proof (microorganism in vegetation/abscess OR pathologic lesions) | Yes (+1) |
|---|---|
| Major: typical IE blood-culture / molecular criterion met | Yes (+1) |
| Major: imaging (echo/CT/PET) OR surgical major criterion met | Yes (+1) |
| Minor: predisposition (prior IE, prosthetic valve, CHD, IDU, etc.) | Yes (+1) |
| Minor: fever ≥38.0 °C | Yes (+1) |
| Minor: vascular phenomena | Yes (+1) |
| Minor: immunologic phenomena | Yes (+1) |
| Minor: microbiologic evidence not meeting major | Yes (+1) |
| Clear alternative diagnosis OR resolution ≤4 d antibiotics OR no IE at surgery/autopsy | Yes (+1) |
→Duke-ISCVIDDefinite
- Cue：Pathologic criteria fulfilled
Verification & sources · governance
FAQ
Frequently asked questions
- Does Duke-ISCVID 2023 IE Criteria upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is Duke-ISCVID 2023 IE Criteria calculated in practice? Can you show a worked example?
- Inputs: Pathologic proof (microorganism in vegetation/abscess OR pathologic lesions) No (0), Major: typical IE blood-culture / molecular criterion met No (0), Major: imaging (echo/CT/PET) OR surgical major criterion met No (0), Minor: predisposition (prior IE, prosthetic valve, CHD, IDU, etc.) No (0), Minor: fever ≥38.0 °C No (0), Minor: vascular phenomena No (0), Minor: immunologic phenomena No (0), Minor: microbiologic evidence not meeting major No (0)… → Result: Duke-ISCVID Rejected（Major / minor: 0 / 0） Inputs: Pathologic proof (microorganism in vegetation/abscess OR pathologic lesions) Yes (+1), Major: typical IE blood-culture / molecular criterion met Yes (+1), Major: imaging (echo/CT/PET) OR surgical major criterion met Yes (+1), Minor: predisposition (prior IE, prosthetic valve, CHD, IDU, etc.) Yes (+1), Minor: fever ≥38.0 °C Yes (+1), Minor: vascular phenomena Yes (+1), Minor: immunologic phenomena Yes (+1), Minor: microbiologic evidence not meeting major Yes (+1)… → Result: Duke-ISCVID Definite（Cue: Pathologic criteria fulfilled）