🩸 DIPSS (Dynamic IPSS) Myelofibrosis
UseWhen to use: PMF follow-up when cytogenetics/mutations not yet driving MIPSS.
StrataLow 0 / int-1 1–2 / int-2 3–4 / high 5–6.
LimitsWhen not to use: replacing MIPSS when mutations known. · Pitfall: transfusion-Hb timing. · Not a sole transplant mandate.
SourceDIPSS (Passamonti et al., Blood) dynamic myelofibrosis score
This-shift next steps
After scoring: open the scene pack, peer scores, and the matching pathway. Local reference — no HIS write.
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Methodology · worked example, guidelines & full notes
Dynamic score.
When to use
When to use: PMF follow-up when cytogenetics/mutations not yet driving MIPSS.
How it works
Age >65 (+1), WBC >25 (+1), Hb <10 (+2), blasts ≥1% (+1), symptoms (+1).
Key points
- Dynamic score.
- Anemia weighted ×2.
- Next: DIPSS-plus / MIPSS.
References
- DIPSS (Passamonti et al., Blood) dynamic myelofibrosis score
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Age >65 years | No (0) |
|---|---|
| WBC >25 ×10⁹/L | No (0) |
| Hemoglobin <10 g/dL | No (0) |
| Peripheral blasts ≥1% | No (0) |
| Constitutional symptoms (fever, sweats, >10% weight loss/6 mo) | No (0) |
→DIPSS0/6
- Risk group：Low (0)
| Age >65 years | Yes (+1) |
|---|---|
| WBC >25 ×10⁹/L | Yes (+1) |
| Hemoglobin <10 g/dL | Yes (+2) |
| Peripheral blasts ≥1% | Yes (+1) |
| Constitutional symptoms (fever, sweats, >10% weight loss/6 mo) | Yes (+1) |
→DIPSS6/6
- Risk group：High (5–6)
Verification & sources · governance
FAQ
Frequently asked questions
- Does DIPSS (Dynamic IPSS) Myelofibrosis upload patient data? Where is it calculated?
- Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
- How is DIPSS (Dynamic IPSS) Myelofibrosis calculated in practice? Can you show a worked example?
- Inputs: Age >65 years No (0), WBC >25 ×10⁹/L No (0), Hemoglobin <10 g/dL No (0), Peripheral blasts ≥1% No (0), Constitutional symptoms (fever, sweats, >10% weight loss/6 mo) No (0) → Result: DIPSS 0 /6（Risk group: Low (0)） Inputs: Age >65 years Yes (+1), WBC >25 ×10⁹/L Yes (+1), Hemoglobin <10 g/dL Yes (+2), Peripheral blasts ≥1% Yes (+1), Constitutional symptoms (fever, sweats, >10% weight loss/6 mo) Yes (+1) → Result: DIPSS 6 /6（Risk group: High (5–6)）