Clinical tools › Syndrome matcher

Clinical Syndrome Matcher

Search candidate syndromes by signs and symptoms (HPO phenotypes), ranked by phenotype overlap; open ORPHA / OMIM for cross-check.

How to use

Enter a Chinese or English keyword (e.g. Seizure), then Search.
Select one or more phenotypes; remove any selected in error.
Click Match to list candidate syndromes by phenotype overlap.
Each row shows a relative ranking score (not a diagnostic probability) and matched phenotypes.
Suggested follow-up cues (to guide further history; not negative evidence) flag common annotated phenotypes you have not selected — not negative evidence and not grounds for exclusion.

A fixed short disclaimer sits above the results. For licensed clinicians as an adjunct to differential diagnosis only — not a clinical diagnosis or treatment advice.

LanguagePhenotype terms (HPO)

Selected phenotypes (0)

Search and select phenotype terms (multi-select), then Match.

Candidate syndromes (ranked by phenotype overlap)

After selecting phenotypes and clicking Match, candidates appear here ranked by phenotype overlap. Each row shows a relative ranking score (not a diagnostic probability) and a matched summary; expand for overview, phenotype match, follow-up cues, and ORPHA / OMIM links.

This tool is for licensed clinicians as an adjunct to differential diagnosis only and does not constitute a clinical diagnosis or treatment advice.

Results are based on phenotype overlap and weighted ranking using the public Human Phenotype Ontology (HPO) and its disease annotations (HPOA). They cannot replace history, examination, laboratory/imaging, or genetic testing, and cannot alone confirm or exclude any syndrome.

Findings must be interpreted by an appropriately qualified specialist (clinical genetics / relevant specialty recommended). Obtain specialty consultation before establishing a diagnosis or changing management.

Incomplete phenotype selection, mapping error, outdated annotation frequency, or individual variability may skew ranking; absence from the list ≠ exclusion, and a high rank ≠ confirmed diagnosis.

Data notes

Loading data notes…

Source: HPO / HPOA (see Data notes for versions). Yuan Doctor does not provide remote diagnosis.

中文版 →