MASCC Score (Febrile Neutropenia Risk) — free guideline decision tool

Identify low-risk febrile neutropenia with the MASCC score.

Weighted items (burden of illness, no hypotension, no COPD, tumour type, hydration, outpatient status, age) up to 26. ≥ 21 = low risk. Sum weighted MASCC items (burden of illness, hypotension absence, COPD absence, solid tumour or no prior fungal infection, dehydration absence, outpatient onset, age <60) to a maximum of 26.

Decide on outpatient versus inpatient management.

Scores ≥21 identify candidates for carefully selected outpatient oral therapy; <21 favours inpatient IV antibiotics and closer monitoring.

≥ 21 may permit outpatient oral therapy in selected patients. Apply alongside social and clinical criteria. Never override clinical concern.

Never override clinical instability, social barriers, or expected prolonged neutropenia. Apply with local febrile-neutropenia pathways and culture/imaging work-ups. Low-risk designation still needs reliable follow-up and return precautions. For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.

Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.

Inputs: Burden of illness Moderate (3), No hypotension (SBP > 90) No, No COPD No, Solid tumour or no prior fungal infection No, No dehydration needing IV fluids No, Outpatient at fever onset No, Age < 60 No → Result: MASCC 3 /26（Risk: < 21 — high risk; admit for IV antibiotics.） Inputs: Burden of illness None/mild (5), No hypotension (SBP > 90) No, No COPD No, Solid tumour or no prior fungal infection No, No dehydration needing IV fluids No, Outpatient at fever onset No, Age < 60 No → Result: MASCC 5 /26（Risk: < 21 — high risk; admit for IV antibiotics.）