Neonatal Early-Onset Sepsis Risk (Kaiser EOS Framework) — free guideline decision tool
The Kaiser Permanente early-onset sepsis (EOS) framework combines perinatal risk factors with the infant's clinical examination to stratify management in newborns ≥ 34–35 weeks.
Open guideline tool →Guideline-based
Implements the decision logic from published clinical guidelines.
Runs in your browser
No installation. Enter the patient's values and get a guideline recommendation instantly.
Data stays local
Nothing is uploaded. Results are for licensed clinicians only.
Worked calculation
The values below come from this tool's own example placeholders and are computed server-side with the formula shown on this page, so the arithmetic can be checked quickly. It demonstrates how to substitute values only — it is not clinical advice and not a real case.
| Gestational age at birth (applies to ≥ 34–35 wk) | 38 wk |
|---|---|
| Maximum maternal intrapartum temperature | 38.0 °C |
| Duration of rupture of membranes | 12 h |
| Maternal GBS status | Positive |
| Intrapartum antibiotics | GBS-specific (penicillin/ampicillin) ≥ 2 h |
| Neonatal clinical grade | Equivocal |
→Management tierManagement follows current guidelines and local protocols; this page gives no management recommendation.
- Perinatal factors：GA 38 wk, maximum maternal temp 38 °C (maternal fever ≥ 38 °C, increased EOS risk), ROM 12 h, GBS positiveManagement follows current guidelines and local protocols; this page gives no management recommendation.GBS-specific ≥ 2 h
- Management recommendation：Equivocal
- Management-tier thresholds：A change in clinical status warrants re-evaluation/recalculation within 24 h
| Gestational age at birth (applies to ≥ 34–35 wk) | 38 wk |
|---|---|
| Maximum maternal intrapartum temperature | 38.0 °C |
| Duration of rupture of membranes | 12 h |
| Maternal GBS status | Negative |
| Intrapartum antibiotics | None / ≤ 2 h before delivery |
| Neonatal clinical grade | Well-appearing |
→Management tierTier by risk value
- Perinatal factors：GA 38 wk, maximum maternal temp 38 °C (maternal fever ≥ 38 °C, increased EOS risk), ROM 12 h, GBS negativeManagement follows current guidelines and local protocols; this page gives no management recommendation.none/inadequate
- Management recommendation：Well-appearing
- Management-tier thresholds：A change in clinical status warrants re-evaluation/recalculation within 24 h
Common questions
What is Neonatal Early-Onset Sepsis Risk (Kaiser EOS Framework)?
The Kaiser Permanente early-onset sepsis (EOS) framework combines perinatal risk factors with the infant's clinical examination to stratify management in newborns ≥ 34–35 weeks.
How is Neonatal Early-Onset Sepsis Risk (Kaiser EOS Framework) calculated? What is the core formula?
clinical illness.
When is Neonatal Early-Onset Sepsis Risk (Kaiser EOS Framework) used?
Management follows current guidelines and local protocols; this page gives no management recommendation.
What are the key clinical points for Neonatal Early-Onset Sepsis Risk (Kaiser EOS Framework)?
The exact quantitative risk per 1000 live births requires the official online calculator; this framework does not substitute a specific risk number.
What are the limits and cautions when using Neonatal Early-Onset Sepsis Risk (Kaiser EOS Framework)?
For licensed clinicians and clinical researchers. Interpret results with history, investigations and local protocols; not a diagnosis or prescription, and not a substitute for multidisciplinary decision-making or local guidelines.
Does Neonatal Early-Onset Sepsis Risk (Kaiser EOS Framework) upload patient data? Where is it calculated?
Calculation runs locally in the browser; inputs and results are not uploaded. For licensed clinicians only; interpret with history, investigations and local protocols — not a diagnosis or prescription.
How is Neonatal Early-Onset Sepsis Risk (Kaiser EOS Framework) calculated in practice? Can you show a worked example?
Inputs: Gestational age at birth (applies to ≥ 34–35 wk) 38 wk, Maximum maternal intrapartum temperature 38.0 °C, Duration of rupture of membranes 12 h, Maternal GBS status Positive, Intrapartum antibiotics GBS-specific (penicillin/ampicillin) ≥ 2 h, Neonatal clinical grade Equivocal → Result: Management tier Management follows current guidelines and local protocols; this page gives no management recommendation.（Perinatal factors: GA 38 wk, maximum maternal temp 38 °C (maternal fever ≥ 38 °C, increased EOS risk), ROM 12 h, GBS positiveManagement follows current guidelines and local protocols; this page gives no management recommendation.GBS-specific ≥ 2 h, Management recommendation: Equivocal, Management-tier thresholds: A change in clinical status warrants re-evaluation/recalculation within 24 h） Inputs: Gestational age at birth (applies to ≥ 34–35 wk) 38 wk, Maximum maternal intrapartum temperature 38.0 °C, Duration of rupture of membranes 12 h, Maternal GBS status Negative, Intrapartum antibiotics None / ≤ 2 h before delivery, Neonatal clinical grade Well-appearing → Result: Management tier Tier by risk value（Perinatal factors: GA 38 wk, maximum maternal temp 38 °C (maternal fever ≥ 38 °C, increased EOS risk), ROM 12 h, GBS negativeManagement follows current guidelines and local protocols; this page gives no management recommendation.none/inadequate, Management recommendation: Well-appearing, Management-tier thresholds: A change in clinical status warrants re-evaluation/recalculation within 24 h）
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The Kaiser Permanente early-onset sepsis (EOS) framework combines perinatal risk factors with the infant's clinical examination to stratify management in newborns ≥ 34–35 weeks.
Open guideline tool →For licensed clinicians. Not a substitute for clinical judgement.
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